|Application ||WB, IHC-P, IF, IP|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||92469 Da|
|Dilution||IF (1:50 - 1:200), IHC-P (1:100), IP (1:50 - 1:200), WB (1:500 - 1:1000),|
|Other Names||HSP90B1, ECGP, Endoplasmin, gp96 homolog, gp96, GRP-94, GRP94, Tumor rejection antigen 1, TRA1|
|Target/Specificity||Human GP96 / GRP94|
|Reconstitution & Storage||PBS, pH 7.2, 15 mM sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.|
|Precautions||HSP90B1 / GP96 / GRP94 Antibody (aa211-260) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.|
|Cellular Location||Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
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Provided below are standard protocols that you may find useful for product applications.
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.
Maki R.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:5658-5662(1990).
Chang S.C.,et al.Mol. Cell. Biol. 9:2153-2162(1989).
Meng S.,et al.Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).
Meunier L.,et al.Mol. Biol. Cell 13:4456-4469(2002).
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