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LAMP1 / CD107a Antibody (clone H4A3)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, ICC, IHC-F, FC |
|---|---|
| Primary Accession | P11279 |
| Other Accession | 3916 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | H4A3 |
| Calculated MW | 44882 Da |
| Dilution | ICC (2 - 10 µg/ml), IHC-P (10 µg/ml), IHC-P (10 µg/ml), |
| Gene ID | 3916 |
|---|---|
| Other Names | LAMP1, CD107a, CD107a antigen, LAMP-1, LGP120, LAMPA |
| Target/Specificity | Monoclonal antibody H4A3 recognizes CD107a, an approximately 100-120 kD glycoprotein expressed mainly on lysosomal, but also on the plasma membrane. |
| Reconstitution & Storage | PBS, pH 7.4, sterile filtered. Store at 2-8°C. Do not freeze. |
| Precautions | LAMP1 / CD107a Antibody (clone H4A3) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LAMP1 {ECO:0000303|PubMed:23632890, ECO:0000312|HGNC:HGNC:6499} |
|---|---|
| Function | Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:37390818). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (PubMed:37390818). Also plays an important role in NK-cells cytotoxicity (PubMed:2022921, PubMed:23632890). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins (PubMed:7685349). |
| Cellular Location | Lysosome membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Cytolytic granule membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). {ECO:0000250|UniProtKB:P05300, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319} |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
References
Fukuda M.,et al.J. Biol. Chem. 263:18920-18928(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Mane S.M.,et al.Arch. Biochem. Biophys. 268:360-378(1989).
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