|Application ||WB, IHC-P, ICC, IHC-Fr, Flo|
|Calculated MW||44882 Da|
|Dilution||ICC (2 - 10 µg/ml), IHC-P (10 µg/ml), IHC-P (10 µg/ml),|
|Other Names||LAMP1, CD107a, CD107a antigen, LAMP-1, LGP120, LAMPA|
|Target/Specificity||Monoclonal antibody H4A3 recognizes CD107a, an approximately 100-120 kD glycoprotein expressed mainly on lysosomal, but also on the plasma membrane.|
|Reconstitution & Storage||PBS, pH 7.4, sterile filtered. Store at 2-8°C. Do not freeze.|
|Precautions||LAMP1 / CD107a Antibody (clone H4A3) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein Lysosome membrane; Single-pass type I membrane protein. Late endosome. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome|
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Provided below are standard protocols that you may find useful for product applications.
Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
Fukuda M.,et al.J. Biol. Chem. 263:18920-18928(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Mane S.M.,et al.Arch. Biochem. Biophys. 268:360-378(1989).
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