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>   home   >   Products   >   Primary Antibodies   >   TJP1 / ZO-1 Antibody (aa1-296)   

TJP1 / ZO-1 Antibody (aa1-296)

Rabbit Polyclonal Antibody

     
  • IHC - TJP1 / ZO-1 Antibody (aa1-296) ALS16946
    Anti-TJP1 / ZO-1 antibody IHC staining of human testis.
  • ICC - TJP1 / ZO-1 Antibody (aa1-296) ALS16946
    ZO-1 antibody, N-term detects TJP1 protein at junction by confocal immunofluorescent analysis.
  • WB - TJP1 / ZO-1 Antibody (aa1-296) ALS16946
    Sample (30 ug whole cell lysate). A: H1299. 5% SDS PAGE. ZO-1 antibody diluted at 1:3000
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC
Primary Accession Q07157
Other Accession 7082
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 195459 Da
Dilution ICC (1:100 - 1:1000), IHC-P (10 µg/ml), WB (1:500 - 1:3000),
Additional Information
Gene ID 7082
Other Names TJP1, ZO-1, Zona occludens protein 1, Zona occludens 1, Zonula occludens protein 1, Tight junction protein 1, ZO1, Tight junction protein ZO-1, Zonula occludens 1 protein
Target/Specificity Human ZO-1
Reconstitution & Storage 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsTJP1 / ZO-1 Antibody (aa1-296) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TJP1
Synonyms ZO1
Function The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.
Cellular Location Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Cell junction Cell junction, gap junction. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells
Tissue Location The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules
Citations (0)

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Background

The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.

References

Willott E.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:7834-7838(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Cohen C.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:15191-15196(2001).
D'Atri F.,et al.J. Biol. Chem. 277:27757-27764(2002).

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$ 395.00
Cat# ALS16946
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