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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GSN / Gelsolin Antibody (clone GEL-42)   

GSN / Gelsolin Antibody (clone GEL-42)

Mouse Monoclonal Antibody

     
  • IHC - GSN / Gelsolin Antibody (clone GEL-42) ALS16957
    Anti-GSN / Gelsolin antibody IHC staining of human thymus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IHC-Fr
Primary Accession P06396
Other Accession 2934
Reactivity Human, Rabbit, Bovine
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names GEL-42
Calculated MW 85698 Da
Dilution IHC-Fr (1 - 2 µg/ml), IHC-P (1 - 10 µg/ml), WB (0.5 - 1 µg/ml),
Additional Information
Gene ID 2934
Other Names GSN, ADF, AGEL, Brevin, Actin-depolymerizing factor, Gelsolin precursor, plasma, Gelsolin
Target/Specificity Human, rabbit, bovine. No cross reactivity with other proteins.
Reconstitution & Storage 1.2% sodium acetate, 2 mg BSA, 0.01 mg sodium azide as preservative. Short term +4°C; Long term -20°C
PrecautionsGSN / Gelsolin Antibody (clone GEL-42) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GSN
Function Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Cellular Location Isoform 2: Cytoplasm, cytoskeleton.
Tissue Location Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells
Volume 50 µl
Research Areas
Citations (0)

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Background

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.

References

Kwiatkowski D.J.,et al.Nature 323:455-458(1986).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).

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$ 395.00
Cat# ALS16957
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