|Application ||WB, IHC-P, IHC-Fr|
|Reactivity||Human, Rabbit, Bovine|
|Calculated MW||85698 Da|
|Dilution||IHC-Fr (1 - 2 µg/ml), IHC-P (1 - 10 µg/ml), WB (0.5 - 1 µg/ml),|
|Other Names||GSN, ADF, AGEL, Brevin, Actin-depolymerizing factor, Gelsolin precursor, plasma, Gelsolin|
|Target/Specificity||Human, rabbit, bovine. No cross reactivity with other proteins.|
|Reconstitution & Storage||1.2% sodium acetate, 2 mg BSA, 0.01 mg sodium azide as preservative. Short term +4°C; Long term -20°C|
|Precautions||GSN / Gelsolin Antibody (clone GEL-42) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.|
|Cellular Location||Isoform 2: Cytoplasm, cytoskeleton.|
|Tissue Location||Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Kwiatkowski D.J.,et al.Nature 323:455-458(1986).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.