|Application ||WB, IHC-P, IF|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||19258 Da|
|Dilution||IF (1:50 - 1:200), IHC-P (5 µg/ml), WB (1:500 - 1:1000),|
|Other Names||PRAF2, JM4, Jena-Muenchen 4, PRA1 domain family, member 2, PRA1 family protein 2, PRA1 domain family 2|
|Target/Specificity||Human JM4 / PRAF2|
|Reconstitution & Storage||PBS, pH 7.2, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.|
|Precautions||PRAF2 Antibody (aa141-190) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis.|
|Cellular Location||Endosome membrane; Multi-pass membrane protein|
|Tissue Location||Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumor tissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. High expression in neuroblastic tumors. Strongly expressed in Purkinje cells and more moderately in cells of the molecular and the granular layers in the cerebellum. Detected in neuronal cells, but not in non- neuronal cells in the cerebral cortex, hippocampus, and lateral ventricles.|
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May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis.
Strom T.M.,et al.Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Schweneker M.,et al.FEBS Lett. 579:1751-1758(2005).
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