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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IKBKG / NEMO / IKK Gamma Antibody (aa51-100)   

IKBKG / NEMO / IKK Gamma Antibody (aa51-100)

Rabbit Polyclonal Antibody

     
  • IHC - IKBKG / NEMO / IKK Gamma Antibody (aa51-100) ALS16964
    Anti-IKBKG / NEMO / IKK Gamma antibody IHC staining of human kidney.
  • IF - IKBKG / NEMO / IKK Gamma Antibody (aa51-100) ALS16964
    Immunofluorescence of HeLa cells, using IKK-gamma (Ab-85) Antibody.
  • WB - IKBKG / NEMO / IKK Gamma Antibody (aa51-100) ALS16964
    Western blot of extracts from HepG2 cells, treated with Anisomycin 0.5 uM 5h, using IKK-gamma...
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9Y6K9
Other Accession 8517
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 48198 Da
Dilution ELISA (1:1000), IF (1:100 - 1:500), IHC-P (5 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 8517
Other Names IKBKG, AMCBX1, FIP3, Fip3p, IkappaB kinase gamma, IKKgamma, IKK-gamma, NEMO, NF-kappa-B essential modifier, I-kappa-B kinase gamma-subunit, I-kappa-B kinase subunit gamma, IkB kinase gamma subunit, IKKAP1, Incontinentia pigmenti, IP2, IPD2, NF-kappa- ...
Target/Specificity Detects endogenous levels of total IKK-gamma protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsIKBKG / NEMO / IKK Gamma Antibody (aa51-100) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IKBKG
Synonyms FIP3, NEMO
Function Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
Cellular Location Cytoplasm. Nucleus. Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress
Tissue Location Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
Research Areas
Citations (0)

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Background

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.

References

Li Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047(1999).
Jin D.-Y.,et al.J. Biomed. Sci. 6:115-120(1999).
Rothwarf D.M.,et al.Nature 395:297-300(1998).
Smahi A.,et al.Nature 405:466-472(2000).
Ye Z.,et al.Biochem. Biophys. Res. Commun. 275:223-227(2000).

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$ 395.00
Cat# ALS16964
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