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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GJA1 / CX43 / Connexin 43 Antibody (aa340-390)   

GJA1 / CX43 / Connexin 43 Antibody (aa340-390)

Rabbit Polyclonal Antibody

     
  • IHC - GJA1 / CX43 / Connexin 43 Antibody (aa340-390) ALS16975
    Anti-GJA1 / CX43 / Connexin 43 antibody IHC staining of human brain, cortex.
  • WB - GJA1 / CX43 / Connexin 43 Antibody (aa340-390) ALS16975
    Western blot analysis of Connexin 43 pAb at a 1:500 dilution.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P17302
Other Accession 2697
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 43008 Da
Dilution IF (1:50 - 1:200), IHC-P (5 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 2697
Other Names GJA1, Connexin-43, DFNB38, Connexin 43, Gap junction alpha-1 protein, GJAL, HSS, Gap junction protein alpha 1, ODDD, ODD, AVSD3, CX43, HLHS1, ODOD, SDTY3
Target/Specificity Human GJA1 / Connexin 43
Reconstitution & Storage PBS, pH 7.2, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PrecautionsGJA1 / CX43 / Connexin 43 Antibody (aa340-390) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GJA1
Synonyms GJAL
Function Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum {ECO:0000250|UniProtKB:P23242}. Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and the proper localization at ICD is dependent on TMEM65. {ECO:0000250|UniProtKB:P23242}
Tissue Location Expressed in the heart and fetal cochlea.
Research Areas
Citations (0)

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Background

Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity).

References

Fishman G.I.,et al.J. Cell Biol. 111:589-598(1990).
Fishman G.I.,et al.Genomics 10:250-256(1991).
Haefliger J.-A.,et al.Eur. Heart J. 20:1843-1843(1999).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS16975
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