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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CAV1 / Caveolin 1 Antibody (aa2-104)   

CAV1 / Caveolin 1 Antibody (aa2-104)

Rabbit Polyclonal Antibody

     
  • IHC - CAV1 / Caveolin 1 Antibody (aa2-104) ALS17009
    Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - CAV1 / Caveolin 1 Antibody (aa2-104) ALS17009
    Western blot of recombinant CAV1 / Caveolin 1.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q03135
Other Accession 857
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 20472 Da
Dilution ELISA (1:100 - 1:200), IHC-P (1:100), WB (1:100 - 1:400),
Additional Information
Gene ID 857
Other Names CAV1, Caveolin-1, CGL3, CAV, MSTP085, VIP21, BSCL3
Target/Specificity Human CAV1 / Caveolin 1
Reconstitution & Storage PBS, pH 7.4, 0.02% sodium azide, 50% glycerol. Store frozen product at or below -20°C. Thawed product may be stored for 2-4 weeks at 4°C. For optimal storage, aliquot to smaller portions and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
PrecautionsCAV1 / Caveolin 1 Antibody (aa2-104) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAV1
Synonyms CAV
Function May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292).
Cellular Location Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane Membrane protein of caveolae
Tissue Location Expressed in muscle and lung, less so in liver, brain and kidney
Research Areas
Citations (0)

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Background

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.

References

Glenney J.R. Jr.,et al.FEBS Lett. 314:45-48(1992).
Hurlstone A.F.,et al.Oncogene 18:1881-1890(1999).
Engelman J.A.,et al.FEBS Lett. 448:221-230(1999).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Vainonen J.P.,et al.Biochem. Biophys. Res. Commun. 320:480-486(2004).

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$ 395.00
Cat# ALS17009
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