|Application ||WB, IHC-P|
|Calculated MW||23356 Da|
|Dilution||IHC-P (10 µg/ml), WB (1:2000),|
|Other Names||GSTP1, Deafness, X-linked 7, DFN7, GSTP1-1, Glutathione S-transferase P, GST Pi, GSTP, FAEES3, Glutathione S-transferase pi 1, GST class-pi, GST3, PI|
|Target/Specificity||Human GSTP1 / GST Pi|
|Reconstitution & Storage||PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.|
|Precautions||GSTP1 / GST Pi Antibody (clone 10H1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.|
|Cellular Location||Cytoplasm. Mitochondrion. Nucleus. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization|
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Provided below are standard protocols that you may find useful for product applications.
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Kano T.,et al.Cancer Res. 47:5626-5630(1987).
Cowell I.G.,et al.Biochem. J. 255:79-83(1988).
Morrow C.S.,et al.Gene 75:3-11(1989).
Moscow J.A.,et al.Cancer Res. 49:1422-1428(1989).
Bora P.S.,et al.Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
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