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APG4B / ATG4B Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - APG4B / ATG4B Antibody (C-Terminus) ALS17104
    Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC - APG4B / ATG4B Antibody (C-Terminus) ALS17104
    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IF - APG4B / ATG4B Antibody (C-Terminus) ALS17104
    Immunofluorescence of ATG4B in human spleen tissue with ATG4B antibody at 20 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9Y4P1
Other Accession 23192
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 44294 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 23192
Other Names ATG4B, APG4 autophagy 4 homolog B, AUTL1, Autophagin-1, Cysteine protease ATG4B, HAPG4B, APG4B, KIAA0943
Target/Specificity ATG4B antibody is human, mouse and rat reactive. At least two isoforms of ATG4B are known to exist; this antibody will detect only the larger isoform. ATG4B is predicted to not cross-react with other ATG4 proteins.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsAPG4B / ATG4B Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATG4B
Synonyms APG4B, AUTL1, KIAA0943
Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C- terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Cellular Location Cytoplasm.
Tissue Location Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas
Research Areas
Citations (0)

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Background

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C- terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

References

Marino G.,et al.J. Biol. Chem. 278:3671-3678(2003).
Kabeya Y.,et al.J. Cell Sci. 117:2805-2812(2004).
Nagase T.,et al.DNA Res. 6:63-70(1999).
Ohara O.,et al.Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS17104
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