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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   WWC1 / KIBRA Antibody (N-Terminus)   

WWC1 / KIBRA Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - WWC1 / KIBRA Antibody (N-Terminus) ALS17127
    Immunohistochemistry of WWC1 in mouse brain tissue with WWC1 antibody at 5 ug/ml.
  • IHC - WWC1 / KIBRA Antibody (N-Terminus) ALS17127
    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC - WWC1 / KIBRA Antibody (N-Terminus) ALS17127
    Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IF - WWC1 / KIBRA Antibody (N-Terminus) ALS17127
    Immunofluorescence of WWC1 in mouse brain tissue with WWC1 antibody at 20 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8IX03
Other Accession 23286
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 125301 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 23286
Other Names WWC1, HBeAg-binding protein 3, HBEBP3, KIBRA, HBEBP36, KIAA0869, Kidney and brain protein, Protein KIBRA, Protein WWC1, WW domain-containing protein 1, WW and C2 domain containing 1
Target/Specificity WWC1 antibody is human, mouse and rat reactive. At least three isoforms of WWC1 are known to exist; this antibody will detect all three isoforms.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsWWC1 / KIBRA Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WWC1
Synonyms KIAA0869
Function Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.
Cellular Location Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell projection, ruffle membrane. Note=Colocalizes with PRKCZ in the perinuclear region
Tissue Location Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules and in the collecting duct
Research Areas
Citations (0)

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Background

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.

References

Kremerskothen J.,et al.Biochem. Biophys. Res. Commun. 300:862-867(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Nagase T.,et al.DNA Res. 5:355-364(1998).

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$ 395.00
Cat# ALS17127
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