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GRK2 Antibody

Rabbit Polyclonal Antibody

     
  • IHC-P - GRK2 Antibody ALS17170
    Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P25098
Other Accession 156
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 79574 Da
Dilution IHC-P (10 µg/ml),
Additional Information
Gene ID 156
Other Names ADRBK1, BARK1, Beta-ARK-1, BETA-ARK1, BARK, Betaark1, GRK2
Target/Specificity Human GRK2
Reconstitution & Storage PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsGRK2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRK2 (HGNC:289)
Synonyms ADRBK1, BARK, BARK1
Function Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:P21146}. Cell membrane {ECO:0000250|UniProtKB:P21146}
Tissue Location Expressed in peripheral blood leukocytes.
Research Areas
Citations (0)

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Background

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

References

Benovic J.L.,et al.FEBS Lett. 283:122-126(1991).
Chuang T.T.,et al.J. Biol. Chem. 267:6886-6892(1992).
Penn R.B.,et al.J. Biol. Chem. 269:14924-14930(1994).
Aragay A.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:2985-2990(1998).
Oppermann M.,et al.J. Biol. Chem. 274:8875-8885(1999).

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$ 395.00
Cat# ALS17170
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