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SNAI1 / SNAIL-1 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC-P - SNAI1 / SNAIL-1 Antibody (Internal) ALS17190
    Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IF - SNAI1 / SNAIL-1 Antibody (Internal) ALS17190
    Confocal immunofluorescence analysis of paraformaldehyde-fixed HeLa, using SNAI1 antibody...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession O95863
Other Accession 6615
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 29083 Da
Dilution ICC (1:100 - 1:1000), IF (1:100 - 1:1000), IHC-P (10 µg/ml),
Additional Information
Gene ID 6615
Other Names SNAI1, DJ710H13.1, Protein sna, SNAIL, Snail 1, Snail 1, zinc finger protein, Snail homolog 1 (Drosophila), SNA, Snail 1 homolog, Protein snail homolog 1, SNAH, Snail 1 zinc finger protein, Zinc finger protein SNAI1, SLUGH2, SNAIL1
Target/Specificity Human SNAI1 / SNAIL-1.
Reconstitution & Storage PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsSNAI1 / SNAIL-1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNAI1
Synonyms SNAH
Function Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Cellular Location Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs
Tissue Location Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.
Volume 50 µl
Research Areas
Citations (0)

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Background

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

References

Okubo T.,et al.Cancer Res. 61:1338-1346(2001).
Twigg S.R.,et al.Hum. Genet. 105:320-326(1999).
Paznekas W.A.,et al.Genomics 62:42-49(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).

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$ 395.00
Cat# ALS17190
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