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NOXO1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC-P - NOXO1 Antibody (C-Terminus) ALS17196
    Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - NOXO1 Antibody (C-Terminus) ALS17196
    Sample (30 ug of whole cell lysate). A: HCT116 10% SDS PAGE. NOXO1 antibody diluted at 1:1000.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q8NFA2
Other Accession 124056
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 41253 Da
Dilution IHC-P (10 µg/ml), WB (1:500 - 1:3000),
Additional Information
Gene ID 124056
Other Names NOXO1, NADPH oxidase organizer 1, Nox-organizing protein 1, p41NOX, p41NOXA, p41NOXC, Regulatory protein P41NOX, Nox organizer 1, p41NOXB, SH3PXD5, SNX28
Target/Specificity Human NOXO1
Reconstitution & Storage 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsNOXO1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NOXO1
Synonyms P41NOX, SH3PXD5
Function Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
Cellular Location Isoform 3: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner
Tissue Location Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis.
Volume 50 µl
Research Areas
Citations (0)

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Background

Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.

References

Banfi B.,et al.J. Biol. Chem. 278:3510-3513(2003).
Geiszt M.,et al.J. Biol. Chem. 278:20006-20012(2003).
Takeya R.,et al.J. Biol. Chem. 278:25234-25246(2003).
Cheng G.,et al.J. Biol. Chem. 279:4737-4742(2004).
Cheng G.,et al.Gene 356:118-126(2005).

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$ 395.00
Cat# ALS17196
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