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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CAPN2 / Calpain 2 / M-Calpain Antibody (clone 1F4)   

CAPN2 / Calpain 2 / M-Calpain Antibody (clone 1F4)

Mouse Monoclonal Antibody

     
  • IHC-P - CAPN2 / Calpain 2 / M-Calpain Antibody (clone 1F4) ALS17205
    Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC-P - CAPN2 / Calpain 2 / M-Calpain Antibody (clone 1F4) ALS17205
    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - CAPN2 / Calpain 2 / M-Calpain Antibody (clone 1F4) ALS17205
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CAPN2...
  • WB - CAPN2 / Calpain 2 / M-Calpain Antibody (clone 1F4) ALS17205
    Western blot of extracts (35ug) from 9 different cell lines by using anti-CAPN2 monoclonal...
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, Flo
Primary Accession P17655
Other Accession 824
Reactivity Human, Mouse, Rat, Monkey
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names 1F4
Calculated MW 79995 Da
Dilution Flo (1:100), IHC-P (10 µg/ml), WB (1:500 - 1:2000),
Additional Information
Gene ID 824
Other Names CAPN2, Calpain 2, large subunit, Calpain ii, Calpain, large polypeptide L2, Calpain-2 catalytic subunit, Calpain 2, Calpain large polypeptide L2, Calpain-2 large subunit, CANP 2, Calpain M-type, CANP2, CANPL2, CANPml, M-type calpain, M-calpain, MCANP ...
Target/Specificity Human CAPN2 / Calpain 2 / M-Calpain
Reconstitution & Storage PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsCAPN2 / Calpain 2 / M-Calpain Antibody (clone 1F4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAPN2
Synonyms CANPL2
Function Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity).
Cellular Location Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding
Tissue Location Ubiquitous.
Volume 50 µl
Research Areas
Citations (0)

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Background

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508).

References

Imajoh S.,et al.Biochemistry 27:8122-8128(1988).
Ye Z.,et al.Biochem. Biophys. Res. Commun. 275:223-227(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Hata A.,et al.J. Biol. Chem. 264:6404-6411(1989).

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$ 395.00
Cat# ALS17205
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