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BAD Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q92934 |
| Other Accession | 572 |
| Reactivity | Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Sheep, Bovine, Dog, Drosophila |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 18392 Da |
| Dilution | IHC-P (5 µg/ml), |
| Gene ID | 572 |
|---|---|
| Other Names | BAD, BBC2, Bcl-2-like protein 8, BCL2-binding component 6, BCL2L8, BBC6, BCL-X/BCL-2 binding protein, Bcl-2-binding component 6, Bcl2 antagonist of cell death, BCL2-binding protein, Bcl2-L-8 |
| Reconstitution & Storage | PBS, pH 7.2, 50% glycerol, 0.09% azide. Store at -20°C. |
| Precautions | BAD Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BAD |
|---|---|
| Synonyms | BBC6, BCL2L8 |
| Function | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. |
| Cellular Location | Mitochondrion outer membrane. Cytoplasm {ECO:0000250|UniProtKB:Q61337}. Note=Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm. {ECO:0000250|UniProtKB:Q61337} |
| Tissue Location | Expressed in a wide variety of tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
References
Yin D.X.,et al.Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
Wang H.-G.,et al.Cell 87:629-638(1996).
Takayama S.,et al.Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
Ottilie S.,et al.J. Biol. Chem. 272:30866-30872(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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