|Application ||IHC-P, E|
|Calculated MW||35092 Da|
|Dilution||ELISA (1:20000 - 1:80000), IHC-P (1:100)|
|Other Names||ASGR2, ASGPR2, Asialoglycoprotein receptors 2, ASGP-R 2, ASGPR 2, ASGP-R2, Asialoglycoprotein receptor 2, CLEC4H2, Hepatic lectin H2, HL-2, HBxAg-binding protein, HBXBP|
|Reconstitution & Storage||PBS, pH 7.4, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||Anti-ASGR2 Antibody (aa106-286) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed exclusively in hepatic parenchymal cells|
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