|Application ||WB, IHC-P, IF|
|Predicted||Human, Mouse, Rat|
|Calculated MW||38580 Da|
|Dilution||IF (1:50 - 1:200), IHC-P (1:100), WB (1:500 - 1:2000)|
|Other Names||PCBP2, Alpha-CP2, HnRNP E2, HNRPE2, Poly(rC) binding protein 2, Poly(rC)-binding protein 2, HnRNP-E2|
|Target/Specificity||Human HNRNP-E2 / PCBP2|
|Reconstitution & Storage||PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles.|
|Precautions||Anti-HNRNP-E2 / PCBP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509).|
|Cellular Location||Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm|
|Tissue Location||Detected in all tissues examined.|
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