|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Monkey|
|Calculated MW||74179 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:1000)|
|Other Names||CD180, CD180 antigen, Lymphocyte antigen 64, Ly78, LY64, CD180 molecule, RP105|
|Target/Specificity||Recognizes endogenous levels of CD180 protein.|
|Reconstitution & Storage||PBS, pH 7.3, 0.01% sodium azide, 30% glycerol. Store at -20°C. Aliquot to avoid freeze/thaw cycles.|
|Precautions||Anti-RP105 / CD180 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells|
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