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Anti-IL1F9 Antibody (clone 2F4)

Mouse Anti Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NZH8
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 2F4
Calculated MW 18721 Da
Dilution IF (1:100), IHC-P (10 µg/ml), WB (1:4000)
Additional Information
Gene ID 56300
Alias Symbol IL36G
Other Names IL36G, IL-1 related protein 2, IL-1-related protein 2, IL-1RP2, IL-1(EPSILON), IL1E, IL1F9, Interleukin-1 epsilon, Interleukin-36 gamma, IL-1F9, IL1H1, Interleukin 1 family, member 9, Interleukin-1 homolog 1, IL-1 epsilon, IL-1-epsilon, IL-1H1, IL1RP ...
Target/Specificity Human IL1F9
Reconstitution & Storage PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide Store at -20°C. Minimize freezing and thawing.
PrecautionsAnti-IL1F9 Antibody (clone 2F4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL36G
Synonyms IL1E, IL1F9, IL1H1, IL1RP2
Function Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.
Cellular Location Secreted.
Tissue Location Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. Expressed in bronchial epithelial. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up- regulated in lesional psoriasis skin. Expressed in monocyte- derived dendritic cells and M1 macrophages
Research Areas
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$ 395.00
Cat# ALS17402
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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