|Application ||WB, IHC-P, IF|
|Calculated MW||18721 Da|
|Dilution||IF (1:100), IHC-P (10 µg/ml), WB (1:4000)|
|Other Names||IL36G, IL-1 related protein 2, IL-1-related protein 2, IL-1RP2, IL-1(EPSILON), IL1E, IL1F9, Interleukin-1 epsilon, Interleukin-36 gamma, IL-1F9, IL1H1, Interleukin 1 family, member 9, Interleukin-1 homolog 1, IL-1 epsilon, IL-1-epsilon, IL-1H1, IL1RP ...|
|Reconstitution & Storage||PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide Store at -20°C. Minimize freezing and thawing.|
|Precautions||Anti-IL1F9 Antibody (clone 2F4) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||IL1E, IL1F9, IL1H1, IL1RP2|
|Function||Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.|
|Tissue Location||Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. Expressed in bronchial epithelial. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up- regulated in lesional psoriasis skin. Expressed in monocyte- derived dendritic cells and M1 macrophages|
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