Anti-SCN8A / Nav1.6 Antibody (N-Terminus)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q9UQD0 |
Predicted | Human, Mouse, Rat, Rabbit, Monkey, Sheep, Bovine, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 225280 Da |
Dilution | IHC-P (1:100), WB (1:500 - 1:1000) |
Gene ID | 6334 |
---|---|
Alias Symbol | SCN8A |
Other Names | SCN8A, CERIII, MED, PN4, Na6, NaCh6, CIAT, Dmu, EIEE13, Motor endplate disease, Nav1.6, PN4a |
Target/Specificity | Recognizes endogenous levels of Nav1.6 protein. |
Reconstitution & Storage | PBS, pH 7.3, 0.01% sodium azide, 30% glycerol. Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
Precautions | Anti-SCN8A / Nav1.6 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SCN8A |
---|---|
Synonyms | MED |
Function | Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:29726066). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:Q9WTU3}. Note=Mainly localizes to the axon initial segment. {ECO:0000250|UniProtKB:Q9WTU3} |
Tissue Location | Expressed in the hippocampus with increased expression in epileptic tissue compared to normal adjacent tissue (at protein level) (PubMed:28842554). Isoform 5: Expressed in non-neuronal tissues, such as monocytes/macrophages. |
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