|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat, Rabbit, Monkey, Sheep, Bovine, Dog|
|Calculated MW||225280 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:1000)|
|Other Names||SCN8A, CERIII, MED, PN4, Na6, NaCh6, CIAT, Dmu, EIEE13, Motor endplate disease, Nav1.6, PN4a|
|Target/Specificity||Recognizes endogenous levels of Nav1.6 protein.|
|Reconstitution & Storage||PBS, pH 7.3, 0.01% sodium azide, 30% glycerol. Store at -20°C. Aliquot to avoid freeze/thaw cycles.|
|Precautions||Anti-SCN8A / Nav1.6 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Isoform 5 is expressed in non-neuronal tissues, such as monocytes/macrophages|
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