|Application ||WB, IHC-P|
|Calculated MW||104924 Da|
|Dilution||IHC-P (5 µg/ml), WB (0.5 - 1 µg/ml)|
|Other Names||ENPP1, Alkaline phosphodiesterase I, ARHR2, E-NPP 1, Ly-41 antigen, NPP1, NPPS, PC1, PDNP1, Alkaline phosphodiesterase 1, M6S1, PCA1, Pc-1|
|Target/Specificity||ENPP1 Antibody detects human ENPP1.|
|Reconstitution & Storage||Lyophilized from PBS, pH 7.4, 0.02% sodium azide. Store lyophilized at -20°C. The reconstituted product can be stored for short term at 4 °C or long term at -20 °C or below. Avoid freeze/thaw cycles.|
|Precautions||Anti-ENPP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||M6S1, NPPS, PC1, PDNP1|
|Function||By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity and function.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Basolateral cell membrane; Single-pass type II membrane protein. Secreted. Note=The proteolytically processed form is secreted (By similarity). Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side|
|Tissue Location||Expressed in plasma cells and also in a number of non-lymphoid tissues, including the distal convoluted tubule of the kidney, chondrocytes and epididymis|
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