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Anti-MST1R / RON Antibody (Internal)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q04912
Predicted Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 152271 Da
Dilution IHC-P (2.4 µg/ml)
Additional Information
Gene ID 4486
Alias Symbol MST1R
Other Names MST1R, C-met-related tyrosine kinase, CD136, CDw136, CD136 antigen, Friend virus susceptibility 2, Fv2, MSP receptor, p185-Ron, PTK8 protein tyrosine kinase 8, RON, Soluble RON variant 3, Soluble RON variant 1, MST1R variant RON30, Oncogene RON, PTK8 ...
Target/Specificity Human MST1R / RON. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-MST1R / RON Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MST1R
Synonyms PTK8, RON
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in colon, skin, lung and bone marrow.
Research Areas
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$ 395.00
Cat# ALS17568
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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