|Predicted||Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Bovine, Horse, Dog|
|Calculated MW||26183 Da|
|Dilution||IHC-P (5 - 10 µg/ml)|
|Other Names||UCHL3, Ubiquitin thiolesterase, Ubiquitin thioesterase L3, UCH-L3|
|Target/Specificity||Human UCHL3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-UCHL3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.|
|Tissue Location||Highly expressed in heart, skeletal muscle, and testis.|
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