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Anti-IPO7 / RANBP7 Antibody (aa1026-1038)

Goat Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95373
Predicted Human, Mouse, Rat, Hamster, Monkey, Bovine, Horse, Dog
Host Goat
Clonality Polyclonal
Calculated MW 119517 Da
Dilution ELISA (1:32000), IHC-P (5 µg/ml), WB (1:32000, 0.1 - 1 µg/ml)
Additional Information
Gene ID 10527
Alias Symbol IPO7
Other Names IPO7, Importin-7, Importin 7, Ran-binding protein 7, Imp7, RAN binding protein 7, RanBP7
Target/Specificity Human IPO7 / Importin 7.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-IPO7 / RANBP7 Antibody (aa1026-1038) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IPO7
Synonyms RANBP7
Function Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
Cellular Location Cytoplasm. Nucleus.
Research Areas
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$ 395.00
Cat# ALS17597
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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