|Application ||WB, IHC-P, IP, Flo|
|Calculated MW||43747 Da|
|Dilution||Flo (1:10 - 1:50), IHC-P (10 µg/ml), IP, WB|
|Other Names||CD46, AHUS2, CD46 antigen, MCP, Measles virus receptor, TLX, MIC10, TRA2.10, Membrane cofactor protein|
|Target/Specificity||Recognizes the human CD46 cell surface antigen, a broadly expressed glycoprotein also known as membrane co-factor protein (MCP). CD46 functions as an inhibitor of complement activation limiting the formation and activity of C3 convertases. CD46 is ex ...|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-CD46 Antibody (clone MEM-258) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single- pass type I membrane protein Note=Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide|
|Tissue Location||Expressed by all cells except erythrocytes.|
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