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Anti-CD46 Antibody (clone MEM-258)
Mouse Anti Human Monoclonal Antibody
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Application 
| WB, IHC-P, IP, Flo |
|---|---|
| Primary Accession | P15529 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | MEM-258 |
| Calculated MW | 43747 Da |
| Dilution | Flo (1:10 - 1:50), IHC-P (10 µg/ml), IP, WB |
| Gene ID | 4179 |
|---|---|
| Alias Symbol | CD46 |
| Other Names | CD46, AHUS2, CD46 antigen, MCP, Measles virus receptor, TLX, MIC10, TRA2.10, Membrane cofactor protein |
| Target/Specificity | Recognizes the human CD46 cell surface antigen, a broadly expressed glycoprotein also known as membrane co-factor protein (MCP). CD46 functions as an inhibitor of complement activation limiting the formation and activity of C3 convertases. CD46 is ex ... |
| Reconstitution & Storage | Protein A purified |
| Precautions | Anti-CD46 Antibody (clone MEM-258) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD46 |
|---|---|
| Synonyms | MCP, MIC10 |
| Function | Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single- pass type I membrane protein Note=Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide |
| Tissue Location | Expressed by all cells except erythrocytes. |
Research Areas
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$ 395.00
Cat# ALS17672
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