|Application ||WB, IHC-P, E|
|Calculated MW||48062 Da|
|Dilution||ELISA, IHC-P (5 µg/ml), WB (1:500 - 1:1000)|
|Other Names||TFAP2A, Activator protein 2, AP-2, AP-2a, AP2TF, AP-2alpha, BOFS, TFAP2, Transcription factor AP-2, AP-2 transcription factor, AP2-alpha|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-TFAP2A / AP-2 Antibody (clone 2G5) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.