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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-CSE1L Antibody (clone 2F4)   

Anti-CSE1L Antibody (clone 2F4)

Mouse Anti Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P55060
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,k
Clone Names 2F4
Calculated MW 110417 Da
Dilution ELISA, IF (10 µg/ml), IHC-P (5 µg/ml), WB (1:500 - 1:1000)
Additional Information
Gene ID 1434
Alias Symbol CSE1L
Other Names CSE1L, CAS, CSE1, Exp2, Importin-alpha re-exporter, Exportin-2, XPO2
Reconstitution & Storage Protein A purified
PrecautionsAnti-CSE1L Antibody (clone 2F4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CSE1L
Synonyms CAS, XPO2
Function Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm
Tissue Location Highly expressed in proliferating cells.
Research Areas
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$ 450.00
Cat# ALS17724
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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