|Application ||WB, IHC-P, IF, E|
|Calculated MW||110417 Da|
|Dilution||ELISA, IF (10 µg/ml), IHC-P (5 µg/ml), WB (1:500 - 1:1000)|
|Other Names||CSE1L, CAS, CSE1, Exp2, Importin-alpha re-exporter, Exportin-2, XPO2|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-CSE1L Antibody (clone 2F4) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.|
|Cellular Location||Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm|
|Tissue Location||Highly expressed in proliferating cells.|
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