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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-KCNA5 / Kv1.5 Antibody (C-Terminus)   

Anti-KCNA5 / Kv1.5 Antibody (C-Terminus)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P22460
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 67228 Da
Dilution IHC-P (10 µg/ml), WB (1:1000 - 1:5000)
Additional Information
Gene ID 3741
Alias Symbol KCNA5
Other Names KCNA5, Cardiac potassium channel, HCK1, HPCN1, HuK6, HuKVI, RMK2, PCN1, RK3, ATFB7, KV1.5, Potassium channel 1
Target/Specificity Human 67 kD protein
Reconstitution & Storage Antiserum
PrecautionsAnti-KCNA5 / Kv1.5 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNA5
Function Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Pancreatic islets and insulinoma.
Research Areas
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$ 395.00
Cat# ALS17748
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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