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Anti-NUDT1 / MTH1 Antibody
Rabbit Anti Human Polyclonal Antibody
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- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P36639 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 17952 Da |
| Dilution | ELISA (1:40000), IHC-P (1:100), WB (1:200 - 1:1000) |
| Gene ID | 4521 |
|---|---|
| Alias Symbol | NUDT1 |
| Other Names | NUDT1, 8-oxo-dGTPase, 2-hydroxy-dATP diphosphatase, MutT human homolog 1, Nudix motif 1, MTH1 |
| Target/Specificity | MTH1 antibody detects endogenous levels of MTH1 protein. Not tested with other proteins. |
| Reconstitution & Storage | Purified |
| Precautions | Anti-NUDT1 / MTH1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NUDT1 |
|---|---|
| Synonyms | MTH1 {ECO:0000303|PubMed:7713500} |
| Function | Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:8226881, PubMed:7713500, PubMed:10608900, PubMed:12857738, PubMed:22556419, PubMed:26238318, PubMed:24695224, PubMed:24695225, PubMed:28679043). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (PubMed:10373420). Has also a significant hydrolase activity toward 2- oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:10373420, PubMed:11139615). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205). Through this antimutagenic activity protects cells from oxidative stress (PubMed:8226881, PubMed:7713500, PubMed:10608900, PubMed:12857738, PubMed:24695224, PubMed:24695225, PubMed:30304478, PubMed:32144205). |
| Cellular Location | [Isoform p18]: Cytoplasm, cytosol. Mitochondrion matrix. Nucleus. Note=Mostly present in cytosol (PubMed:7782328). A minor proportion is mitochondrial (PubMed:7782328) A very small amount of the protein is associated with nuclei (PubMed:7782328). |
| Tissue Location | Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes |
Research Areas
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Discontinued
Cat# ALS17760
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