|Application ||WB, IHC-P, E|
|Calculated MW||22520 Da|
|Dilution||ELISA (1:40000), IHC-P (1:100), WB (1:200 - 1:1000)|
|Other Names||NUDT1, 8-oxo-dGTPase, 2-hydroxy-dATP diphosphatase, MutT human homolog 1, Nudix motif 1, MTH1|
|Target/Specificity||MTH1 antibody detects endogenous levels of MTH1 protein. Not tested with other proteins.|
|Reconstitution & Storage||Purified|
|Precautions||Anti-NUDT1 / MTH1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.|
|Cellular Location||Isoform p18: Cytoplasm. Mitochondrion matrix. Nucleus. Note=Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria|
|Tissue Location||Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes|
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