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Anti-NUDT1 / MTH1 Antibody

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P36639
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 22520 Da
Dilution ELISA (1:40000), IHC-P (1:100), WB (1:200 - 1:1000)
Additional Information
Gene ID 4521
Alias Symbol NUDT1
Other Names NUDT1, 8-oxo-dGTPase, 2-hydroxy-dATP diphosphatase, MutT human homolog 1, Nudix motif 1, MTH1
Target/Specificity MTH1 antibody detects endogenous levels of MTH1 protein. Not tested with other proteins.
Reconstitution & Storage Purified
PrecautionsAnti-NUDT1 / MTH1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NUDT1
Synonyms MTH1
Function Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
Cellular Location Isoform p18: Cytoplasm. Mitochondrion matrix. Nucleus. Note=Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria
Tissue Location Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes
Research Areas
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$ 395.00
Cat# ALS17760
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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