|Application ||WB, IHC-P, E|
|Calculated MW||14726 Da|
|Dilution||ELISA, IHC-P (10 µg/ml), SwELISA, WB|
|Other Names||NPPB, BNP, Natriuretic peptides B, Natriuretic peptide B, Natriuretic protein, Brain type natriuretic peptide|
|Target/Specificity||Human BNP and proBNP|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-NPPB / BNP Antibody (clone 57H3) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.|
|Tissue Location||Brain and also in atria, but at much lower levels than ANP|
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