|Calculated MW||46459 Da|
|Dilution||IHC-P (2.8 - 4.6 µg/ml)|
|Other Names||ADRB2, ADRB2R, Adrenoceptor beta 2, surface, ADRBR, B2AR, Beta-2 adrenoceptor, Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, BETA2AR, BAR, Adrenergic beta-2 receptor, Catecholamine receptor|
|Target/Specificity||Human ADRB2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-ADRB2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.|
|Cellular Location||Cell membrane; Multi- pass membrane protein. Early endosome. Note=Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325).|
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