|Calculated MW||426750 Da|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||DMD, BMD, CMD3B, DXS206, Dystrophin, DXS230, DXS239, DXS269, DXS142, DXS268, DXS164, DXS270, DXS272|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-DMD / Dystrophin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin- associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.|
|Cellular Location||Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane Note=In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs) in the presence of ANK2 (By similarity).|
|Tissue Location||Expressed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma. Expressed in brain, muscle, kidney, lung and testis. Isoform 5 is expressed in heart, brain, liver, testis and hepatoma cells. Most tissues contain transcripts of multiple isoforms, however only isoform 5 is detected in heart and liver.|
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