Anti-SHANK2 / SHANK Antibody (aa331-380)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q9UPX8 |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 201261 Da |
Dilution | ELISA, IHC-P (1:50), WB |
Gene ID | 22941 |
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Alias Symbol | SHANK2 |
Other Names | SHANK2, AUTS17, Cortactin binding protein 1, CTTNBP1, CORTBP1, SPANK-3, SHANK, Cortactin-binding protein 1, GKAP/SAPAP interacting protein, KIAA1022, ProSAP1 |
Target/Specificity | SHANK2 Antibody detects endogenous levels of total SHANK2 protein. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-SHANK2 / SHANK Antibody (aa331-380) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SHANK2 |
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Synonyms | CORTBP1, KIAA1022, PROSAP1 |
Function | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. |
Cellular Location | Apical cell membrane. Cytoplasm. Synapse. Postsynaptic density. Cell projection, growth cone. Cell projection, dendritic spine. Note=Colocalizes with cortactin in growth cones in differentiating hippocampal neurons Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity). |
Tissue Location | Isoform 3 is present in epithelial colonic cells (at protein level). |
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