|Application ||WB, IHC-P, E|
|Calculated MW||158822 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||SHANK2, AUTS17, Cortactin binding protein 1, CTTNBP1, CORTBP1, SPANK-3, SHANK, Cortactin-binding protein 1, GKAP/SAPAP interacting protein, KIAA1022, ProSAP1|
|Target/Specificity||SHANK2 Antibody detects endogenous levels of total SHANK2 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-SHANK2 / SHANK Antibody (aa331-380) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CORTBP1, KIAA1022, PROSAP1|
|Function||Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.|
|Cellular Location||Apical cell membrane. Cytoplasm. Cell junction, synapse Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, growth cone Cell projection, dendritic spine. Note=Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity).|
|Tissue Location||Isoform 3 is present in epithelial colonic cells (at protein level).|
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