|Application ||WB, IHC-F, E|
|Calculated MW||92688 Da|
|Dilution||ELISA, IHC-Fr (1:50), WB|
|Other Names||MAP3K11, Mixed lineage kinase 3, MLK3, Protein-tyrosine kinase PTK1, PTK1, SPRK, MLK-3, MEKK11|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-MAP3K11 / MLK3 Antibody (clone 3D11) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Location is cell cycle dependent|
|Tissue Location||Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.|
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