|Application ||WB, IHC-P, E|
|Calculated MW||42252 Da|
|Dilution||ELISA, IHC-P (3 - 10 µg/ml), WB|
|Other Names||HSD3B1, 3BETAHSD, 3-beta-HSD I, 3BH, HSD3B, HSDB3A, HSDB3, Steroid Delta-isomerase, Trophoblast antigen FDO161G, Progesterone reductase, SDR11E1|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-HSD3B1 Antibody (clone 3C11-D4) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17- alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein|
|Tissue Location||Placenta and skin. Predominantly expressed in mammary gland tissue|
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