|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat, Rabbit, Monkey|
|Calculated MW||114757 Da|
|Dilution||ELISA (1:128000), IHC-P (5 µg/ml), WB (0.1 - 0.3 µg/ml)|
|Other Names||ATP2A2, ATP2B, Calcium pump 2, DAR, SR Ca(2+)-ATPase 2, Cardiac Ca2+ ATPase, DD, SERCA2|
|Target/Specificity||Human ATP2A2 / SERCA2. This antibody is expected to recognize both reported isoforms (NP_001672.1; NP_733765.1).|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-ATP2A2 / SERCA2 Antibody (aa658-671) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart|
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