Anti-GLRA1/Glycine Receptor Alpha 1 Antibody (aa373-386)
Goat Anti Rat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P23415 |
Reactivity | Rat |
Predicted | Human, Mouse, Rabbit, Hamster, Pig, Chicken, Bovine, Horse, Dog |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 52624 Da |
Dilution | ELISA (1:128000), IHC-P (5 µg/ml), WB (0.3 - 1 µg/ml) |
Gene ID | 2741 |
---|---|
Alias Symbol | GLRA1 |
Other Names | GLRA1, Alpha 1 glycine Receptor, GlyR alpha 1, GLYRA1, SPD, STHE, Spasmodic, Glycine receptor alpha 1, Glycine receptor, alpha 1, HKPX1, Strychnine binding subunit |
Target/Specificity | Human GLRA1. The immunizing peptide represents part of the cytoplasmic domain. The antibody is not expected to cross-react with other glycine receptor alpha proteins. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-GLRA1/Glycine Receptor Alpha 1 Antibody (aa373-386) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GLRA1 |
---|---|
Function | Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta- alanine (PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity). |
Cellular Location | Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q64018}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q64018}. Synapse {ECO:0000250|UniProtKB:Q64018} Perikaryon {ECO:0000250|UniProtKB:Q64018}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q64018}. Cell membrane; Multi-pass membrane protein |
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