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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-TFB2M Antibody (aa325-338)
Anti-TFB2M Antibody (aa325-338)
Goat Anti Human Polyclonal Antibody
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- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9H5Q4 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 45349 Da |
| Dilution | ELISA (1:64000), IHC-P (5 µg/ml), WB (0.1 - 0.3 µg/ml) |
| Gene ID | 64216 |
|---|---|
| Alias Symbol | TFB2M |
| Other Names | TFB2M, H-mtTFB, H-mtTFB2, HTFB2M, MtTFB2, Hkp1, NS5ATP5 |
| Target/Specificity | Human TFB2M. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-TFB2M Antibody (aa325-338) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TFB2M (HGNC:18559) |
|---|---|
| Synonyms | NS5ATP5 |
| Function | S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603, PubMed:12068295, PubMed:20410300, PubMed:15526033). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non- template strand (PubMed:29149603, PubMed:15526033). Stimulates transcription independently of the methyltransferase activity (PubMed:12897151). |
| Cellular Location | Mitochondrion. |
| Tissue Location | Ubiquitously expressed. |
Research Areas
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