|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat, Rabbit, Monkey, Pig, Xenopus, Bovine, Horse, Guinea Pig|
|Calculated MW||48058 Da|
|Dilution||ELISA (1:32000), IHC-P (5 µg/ml), WB (0.1 - 0.3 µg/ml)|
|Other Names||KRT18, CK-18, Cytokeratin 18, Cytokeratin-18, K18, Keratin 18, CYK18, Keratin-18|
|Target/Specificity||Human KRT18 / Cytokeratin 18. Reported variants represent identical protein: NP_000215.1, NP_954657.1.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-KRT18 / CK18 / Cytokeratin 18 Antibody (aa265-276) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.|
|Cellular Location||Cytoplasm, perinuclear region. Nucleus, nucleolus|
|Tissue Location||Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.|
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