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Anti-VTCN1 / B7-H4 Antibody

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7Z7D3
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 30878 Da
Dilution ELISA, IHC-P (20 µg/ml), WB
Additional Information
Gene ID 79679
Alias Symbol VTCN1
Other Names VTCN1, B7 superfamily member 1, B7 Superfamily, member 1, B7h.5, B7S1, B7H4, PRO1291, VCTN1, RP11-229A19.4, B7 family member, H4, B7-H4, B7X, Protein B7S1
Reconstitution & Storage Caprylic acid and ammonium sulfate precipitation
PrecautionsAnti-VTCN1 / B7-H4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VTCN1 {ECO:0000312|EMBL:EAW56672.1}
Function Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000255, ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16782226}
Tissue Location Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC) Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
Research Areas
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$ 450.00
Cat# ALS17926
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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