Anti-TNFRSF11A / RANK Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q9Y6Q6 |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 66034 Da |
Dilution | ELISA, IHC-P (20 µg/ml), WB |
Gene ID | 8792 |
---|---|
Alias Symbol | TNFRSF11A |
Other Names | TNFRSF11A, CD265, CD265 antigen, ODFR, LOH18CR1, OPTB7, OSTS, PDB2, RANK, Receptor activator of NF-KB, TRANCER, FEO, OFE |
Target/Specificity | Human TNFRSF11A / RANK |
Reconstitution & Storage | Caprylic acid and ammonium sulfate precipitation |
Precautions | Anti-TNFRSF11A / RANK Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TNFRSF11A |
---|---|
Synonyms | RANK |
Function | Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL- mediated osteoclastogenesis (PubMed:9878548). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (By similarity). Involved in the regulation of interactions between T-cells and dendritic cells (By similarity). |
Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Membrane raft {ECO:0000250|UniProtKB:O35305} |
Tissue Location | Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland |
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