|Application ||WB, IHC-P, E|
|Calculated MW||95449 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||NFATC4, NF-ATc4, NFAT3, NF-AT3|
|Target/Specificity||NFAT3 Antibody detects endogenous levels of total NFAT3 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-NFATC4 / NFAT3 Antibody (aa136-185) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.|
|Cellular Location||Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals The subcellular localization of NFATC plays a key role in the regulation of gene transcription|
|Tissue Location||Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus.|
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