|Application ||WB, IHC-P, E|
|Calculated MW||91681 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||LTK, Leukocyte tyrosine kinase, Protein tyrosine kinase 1, TYK1|
|Target/Specificity||LTK Antibody detects endogenous levels of total LTK protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-LTK Antibody (aa206-255) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in non-hematopoietic cell lines and T- and B-cell lines.|
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