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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-LTK Antibody (aa206-255)
Anti-LTK Antibody (aa206-255)
Rabbit Anti Human Polyclonal Antibody
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P29376 |
| Predicted | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 91681 Da |
| Dilution | ELISA, IHC-P (1:50), WB |
| Gene ID | 4058 |
|---|---|
| Alias Symbol | LTK |
| Other Names | LTK, Leukocyte tyrosine kinase, Protein tyrosine kinase 1, TYK1 |
| Target/Specificity | LTK Antibody detects endogenous levels of total LTK protein. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-LTK Antibody (aa206-255) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LTK {ECO:0000303|PubMed:1655406, ECO:0000312|HGNC:HGNC:6721} |
|---|---|
| Function | Receptor with a tyrosine-protein kinase activity (PubMed:10445845, PubMed:20548102, PubMed:30061385). Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:30061385, PubMed:34646012). Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:20548102). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x- Y-Y motif (By similarity). The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival (PubMed:9223670, PubMed:18849880). Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (PubMed:20548102). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in non-hematopoietic cell lines and T- and B-cell lines. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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