|Application ||WB, IHC-P, IF, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||101506 Da|
|Dilution||ELISA, IF, IHC-P (1:50), WB|
|Other Names||GRIA1, AMPA 1, GluR-K1, HBGR1, GLUH1, GLUR1, GLURA, Glutamate receptor 1, GluR-A, GluA1, GluR-1|
|Target/Specificity||GluR1 Antibody detects endogenous levels of total GluR1 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-GRIA1 / GLUR1 Antibody (aa816-865) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density Cell projection, dendrite. Cell projection, dendritic spine. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.|
|Tissue Location||Widely expressed in brain.|
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