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Anti-IFN Beta / Interferon Beta Antibody
Rabbit Anti Human Polyclonal Antibody
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P01574 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 22294 Da |
| Dilution | ELISA, IHC-P (10 µg/ml), WB |
| Gene ID | 3456 |
|---|---|
| Alias Symbol | IFNB1 |
| Other Names | IFNB1, IFF, IFB, IFNB, Interferon beta, Interferon, beta 1, fibroblast, Fibroblast interferon, IFN-beta |
| Target/Specificity | Human IFN Beta / Interferon Beta |
| Reconstitution & Storage | Caprylic acid and ammonium sulfate precipitation |
| Precautions | Anti-IFN Beta / Interferon Beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IFNB1 (HGNC:5434) |
|---|---|
| Synonyms | IFB, IFNB |
| Function | Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli (PubMed:6157094, PubMed:6171735, PubMed:8027027, PubMed:7665574, PubMed:8969169, PubMed:10049744, PubMed:10556041). Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (PubMed:8027027, PubMed:7665574, PubMed:8969169, PubMed:10049744, PubMed:10556041). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (By similarity). Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)- inducible production of tumor necrosis factor (By similarity). Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (By similarity). IFNB1 is more potent than interferon-alpha (IFN- alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity). |
| Cellular Location | Secreted. |
Research Areas
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