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Anti-FUS / TLS Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P35637 |
| Predicted | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 53426 Da |
| Dilution | ELISA, IHC-P (20 µg/ml), WB |
| Gene ID | 2521 |
|---|---|
| Alias Symbol | FUS |
| Other Names | FUS, 75 kDa DNA-pairing protein, ALS6, CHOP, FUS-CHOP, FUS1, Fused in sarcoma, HnRNP-P2, HNRNPP2, Oncogene TLS, RNA-binding protein FUS, TLS, C/EBP-homologous protein, ETM4, Fus-like protein, Oncogene FUS, POMP75 |
| Target/Specificity | Human FUS / Gadd153 |
| Reconstitution & Storage | Caprylic acid and ammonium sulfate precipitation |
| Precautions | Anti-FUS / TLS Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FUS |
|---|---|
| Synonyms | TLS |
| Function | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre- mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). |
| Cellular Location | Nucleus Note=Displays a punctate pattern inside the nucleus and is excluded from nucleoli. |
| Tissue Location | Ubiquitous. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 621.50
Cat# ALS17980
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