|Application ||WB, IHC-P, IF, E, IP|
|Predicted||Human, Hamster, Monkey, Chicken|
|Calculated MW||33670 Da|
|Dilution||ELISA, IF, IHC-P (10 µg/ml), IP, WB (1:100000)|
|Other Names||HNRNPC, HNRPC, HnRNP C1/C2, HNRNP|
|Target/Specificity||This antibody recognizes the two HNRNP C proteins of 41kD (C1) and 43kD (C2) in human cells, and the corresponding proteins in monkey, hamster and chicken.|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-HNRNPC / HNRNP C Antibody (clone 4F4) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6- methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).|
|Cellular Location||Nucleus. Note=Component of ribonucleosomes.|
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