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Anti-TRIM25 Antibody (clone 5C3)

Mouse Anti Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14258
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,k
Clone Names 5C3
Calculated MW 70973 Da
Dilution ELISA, IF (20 µg/ml), IHC-P (3 - 10 µg/ml), WB
Additional Information
Gene ID 7706
Alias Symbol TRIM25
Other Names TRIM25, EFP, Zinc finger protein 147, Z147, Zinc finger protein-147, ZNF147, Tripartite motif containing 25, RING finger protein 147, RNF147, Tripartite motif-containing 25
Target/Specificity Human TRIM25
Reconstitution & Storage Protein A purified
PrecautionsAnti-TRIM25 Antibody (clone 5C3) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM25
Synonyms EFP, RNF147, ZNF147
Function Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.
Cellular Location Cytoplasm. Note=Colocalized with DDX58 at cytoplasmic perinuclear bodies
Tissue Location Ubiquitous..
Research Areas
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$ 450.00
Cat# ALS18005
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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