|Application ||IHC-P, E|
|Calculated MW||45205 Da|
|Dilution||ELISA (1:4000), IHC-P (1:100)|
|Other Names||HP, Binding peptide, Haptoglobin alpha(1S)-beta, Haptoglobin, beta polypeptide, Haptoglobin, Haptoglobin alpha(2FS)-beta, Haptoglobin, alpha polypeptide, HP2ALPHA2, BP, Zonulin, HPA1S|
|Target/Specificity||Does not cross - react with human IgG, transferrin, CRP, albumin, hemoglobin, or a -1 Acid Glycoprotein as determined by competitive ELISA or Immunoblot. Reacts against native and denatured (non-reduced) human haptoglobin in animmuno blot or dot blot ...|
|Reconstitution & Storage||Ascites|
|Precautions||Anti-HP / Haptoglobin Antibody (clone 637400) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.|
|Tissue Location||Expressed by the liver and secreted in plasma.|
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